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Cellosaurus U-87MG-parkin clone 19 (CVCL_C3IF)

[Text version]
Cell line name U-87MG-parkin clone 19
Synonyms U-87MG-PK19; U87-Parkin 19
Accession CVCL_C3IF
Resource Identification Initiative To cite this cell line use: U-87MG-parkin clone 19 (RRID:CVCL_C3IF)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:8607; PRKN (Note=With a N-terminal FLAG tag).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=22431710; DOI=10.1158/0008-5472.CAN-11-3060
Yeo C.W.-S., Ng F.S.L., Chai C., Tan J.M.-M., Koh G.R.-H., Chong Y.K., Koh L.W.-H., Foong C.S.F., Sandanaraj E., Holbrook J.D., Ang B.-T., Takahashi R., Tang C., Lim K.-L.
Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival.
Cancer Res. 72:2543-2553(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3IF
Encyclopedic resources Wikidata; Q114313142
Gene expression databases GEO; GSM729740
GEO; GSM729743
GEO; GSM729746
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6