ID   MCF7-parkin clone 11
AC   CVCL_C3ID
SY   MCF7-PK11; MCF7-PK#11
DR   cancercelllines; CVCL_C3ID
DR   Wikidata; Q114312270
RX   PubMed=20630868;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 8607; PRKN (Note=With a N-terminal FLAG tag).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 10-09-24; Version: 6
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RX   PubMed=20630868; DOI=10.1074/jbc.M110.108241; PMCID=PMC2937954;
RA   Tay S.-P., Yeo C.W.-S., Chai C., Chua P.-J., Tan H.-M., Ang A.X.-Y.,
RA   Yip D.L.-H., Sung J.-X., Tan P.H., Bay B.-H., Wong S.-H., Tang C.,
RA   Tan J.M.-M., Lim K.-L.;
RT   "Parkin enhances the expression of cyclin-dependent kinase 6 and
RT   negatively regulates the proliferation of breast cancer cells.";
RL   J. Biol. Chem. 285:29231-29238(2010).
//