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Cellosaurus MCF7-parkin clone 5 (CVCL_C3IB)

[Text version]
Cell line name MCF7-parkin clone 5
Synonyms MCF7-PK5; MCF7-PK#5
Accession CVCL_C3IB
Resource Identification Initiative To cite this cell line use: MCF7-parkin clone 5 (RRID:CVCL_C3IB)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 8607; PRKN (Note=With a N-terminal FLAG tag).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=20630868; DOI=10.1074/jbc.M110.108241; PMCID=PMC2937954
Tay S.-P., Yeo C.W.-S., Chai C., Chua P.-J., Tan H.-M., Ang A.X.-Y., Yip D.L.-H., Sung J.-X., Tan P.H., Bay B.-H., Wong S.-H., Tang C., Tan J.M.-M., Lim K.-L.
Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells.
J. Biol. Chem. 285:29231-29238(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3IB
Encyclopedic resources Wikidata; Q114312271
Entry history
Entry creation22-Sep-2022
Last entry update10-Sep-2024
Version number6