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Cellosaurus Hep-G2-THRA MUT p.K74E;A264V (CVCL_C3GB)

[Text version]
Cell line name Hep-G2-THRA MUT p.K74E;A264V
Synonyms HepG2 HCC-THRA mutant I; TRalpha1-I; hcI-TRalpha1
Accession CVCL_C3GB
Resource Identification Initiative To cite this cell line use: Hep-G2-THRA MUT p.K74E;A264V (RRID:CVCL_C3GB)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11796; THRA (Note=With p.Lys74Glu and p.Ala264Val).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=19749797; DOI=10.1038/onc.2009.265; PMCID=PMC2787677
Chan I.H., Privalsky M.L.
Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire.
Oncogene 28:4162-4174(2009)

PubMed=21622534; DOI=10.1210/me.2010-0420; PMCID=PMC3146248
Rosen M.D., Chan I.H., Privalsky M.L.
Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas.
Mol. Endocrinol. 25:1311-1325(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3GB
Encyclopedic resources Wikidata; Q114311595
Gene expression databases GEO; GSM721666
GEO; GSM721667
GEO; GSM721668
GEO; GSM721669
GEO; GSM721670
GEO; GSM721671
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number7