| Cell line name |
Ishikawa 3-H-12 PRB-59 |
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| Synonyms |
PRB-59; PRB-Ishikawa |
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| Accession |
CVCL_C3G8 |
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| Resource Identification Initiative |
To cite this cell line use: Ishikawa 3-H-12 PRB-59 (RRID:CVCL_C3G8) |
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| Comments |
Population: Japanese.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:8910; PGR (Note=Isoform B).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295. |
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| Sequence variations |
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Type I endometrial adenocarcinoma (NCIt: C40145) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_D199 (Ishikawa 3-H-12) |
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| Sex of cell |
Female |
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| Age at sampling |
39Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=12517594; DOI=10.1177/107155760301000110
Smid-Koopman E., Blok L.J., Kuhne L.C.M., Burger C.W., Helmerhorst T.J.M., Brinkmann A.O., Huikeshoven F.J.
Distinct functional differences of human progesterone receptors A and B on gene expression and growth regulation in two endometrial carcinoma cell lines.
J. Soc. Gynecol. Investig. 10:49-57(2003) PubMed=26996671; DOI=10.1038/onc.2016.56; PMCID=PMC5031502
Lee I.I., Maniar K.P., Lydon J.P., Kim J.J.
Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells.
Oncogene 35:5191-5201(2016) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_C3G8
|
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| Encyclopedic resources |
Wikidata; Q114311770
|
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| Gene expression databases |
GEO; GSE72708
|
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| Entry history |
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| Entry creation | 22-Sep-2022 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 7 |
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