| Cell line name |
Jurkat RB1-KO |
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| Accession |
CVCL_C3G2 |
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| Resource Identification Initiative |
To cite this cell line use: Jurkat RB1-KO (RRID:CVCL_C3G2) |
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| Comments |
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 9884; RB1.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0065 (Jurkat) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=33990344; DOI=10.1158/2159-8290.CD-20-1554
Lelliott E.J., Kong I.Y., Zethoven M., Ramsbottom K.M., Martelotto L.G., Meyran D., Zhu J.J., Costacurta M., Kirby L., Sandow J.J., Lim L., Dominguez P.M., Todorovski I., Haynes N.M., Beavis P.A., Neeson P.J., Hawkins E.D., McArthur G.A., Parish I.A., Johnstone R.W., Oliaro J., Sheppard K.E., Kearney C.J., Vervoort S.J.
CDK4/6 inhibition promotes antitumor immunity through the induction of T-cell memory.
Cancer Discov. 11:2582-2601(2021) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_C3G2
|
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| Encyclopedic resources |
Wikidata; Q114311802
|
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| Gene expression databases |
GEO; GSM5534224
GEO; GSM5534225
GEO; GSM5534226
GEO; GSM5534227
GEO; GSM5534228
GEO; GSM5534229
|
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| Entry history |
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| Entry creation | 22-Sep-2022 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 5 |
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