Cellosaurus cell line CWRU-C57BL/6-IPTEC (CVCL

Cellosaurus CWRU-C57BL/6-IPTEC (CVCL_C3FC)

Cross-references
Cell line name	CWRU-C57BL/6-IPTEC
Synonyms	Case Western Reserve University-C57BL/6-Immortalized Proximal Tubule Epithelial Cell line
Accession	CVCL_C3FC
Resource Identification Initiative	To cite this cell line use: CWRU-C57BL/6-IPTEC (RRID:CVCL_C3FC)
Comments	Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58). Omics: Transcriptome analysis by RNAseq. Miscellaneous: As no cell line name was provided in the paper, we assigned the name based on the abbreviation of the institution and of the cell line description. Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134. Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57BL/6J.
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=22020933; DOI=10.1074/jbc.M110.212845; PMCID=PMC3234923 Abu Jawdeh B.G., Khan S., Deschenes I., Hoshi M., Goel M., Lock J.T., Shinlapawittayatorn K., Babcock G.T., Lakhe-Reddy S., DeCaro G.J., Yadav S.P., Mohan M.L., Naga Prasad S.V., Schilling W.P., Ficker E., Schelling J.R. Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival. J. Biol. Chem. 286:42435-42445(2011) PubMed=24531551; DOI=10.1172/JCI71863; PMCID=PMC3934167 Khan S., Abu Jawdeh B.G., Goel M., Schilling W.P., Parker M.D., Puchowicz M.A., Yadav S.P., Harris R.C., El-Meanawy A., Hoshi M., Shinlapawittayatorn K., Deschenes I., Ficker E., Schelling J.R. Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis. J. Clin. Invest. 124:1057-1068(2014) PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662 Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A. Transcriptomes of major proximal tubule cell culture models. J. Am. Soc. Nephrol. 32:86-97(2021)
Encyclopedic resources	Wikidata; Q114311315
Gene expression databases	GEO; GSM4009074 GEO; GSM4009075 GEO; GSM4009076
Entry history
Entry creation	22-Sep-2022
Last entry update	10-Sep-2024
Version number	6