ID   NK-NJ
AC   CVCL_C3ES
DR   Wikidata; Q123033194
RX   PubMed=36520345;
CC   Population: Chinese.
CC   Characteristics: IL2 dependent.
CC   Doubling time: 48 hours (PubMed=36520345).
CC   Sequence variation: Mutation; HGNC; HGNC:1133; BTK; Simple; p.Met228Ile (c.684G>A); ClinVar=VCV001686397; Zygosity=Heterozygous (PubMed=36520345).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ile11Glufs*2 (c.30_54del); Zygosity=Heterozygous (PubMed=36520345).
CC   Sequence variation: Mutation; HGNC; HGNC:11367; STAT5B; Simple; p.Asn642His (c.1924A>C); ClinVar=VCV000657518; Zygosity=Heterozygous (PubMed=36520345).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=36520345).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: NK T-cell; CL=CL_0000814.
DI   NCIt; C4684; Nasal type extranodal NK/T-cell lymphoma
DI   ORDO; Orphanet_86879; Extranodal nasal NK/T cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 19-12-24; Version: 3
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RX   PubMed=36520345; DOI=10.1007/s13577-022-00841-y;
RA   Liang J.-H., Wang W.-T., Du K.-X., Xing T.-Y., Wang Y., Wang H., Liu L.,
RA   Guo R., Shao Y., Liang J.-H., Li Y., Shen H.-R., Wang L., Li J.-Y.,
RA   Xu W.;
RT   "Establishment and comprehensive analysis of a new human cell line
RT   (NK-NJ) with NK-cell characteristics established from extranodal
RT   natural killer cell lymphoma/leukemia.";
RL   Hum. Cell 36:835-846(2023).
//