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Cellosaurus A549 GFP-SMAD4 (CVCL_C3C6)

[Text version]
Cell line name A549 GFP-SMAD4
Accession CVCL_C3C6
Resource Identification Initiative To cite this cell line use: A549 GFP-SMAD4 (RRID:CVCL_C3C6)
Comments Population: Caucasian.
Characteristics: Edited by ZFN at the SMAD4 locus to insert a TagGFP2 construct at the C-terminus of the gene.
Transfected with: UniProtKB; Q8WTC6; Aequorea macrodactyla GFP (with p.Lys3Gly, p.Thr9Ala, p.Ser65Cys, p.Phe99Gln, p.Met128Lys, p.Asn144Ser, p.Met153Arg, p.Lys162Glu, p.Val163Ala, p.Ile167Thr, p.Ala206Lys, p.Thr214Ala, p.Phe220Leu, p.Phe223Ser, p.Gly228Cys and Lys238Arg = TagGFP2).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Web pages https://www.sigmaaldrich.com/catalog/product/sigma/cll1167
Cross-references
Cell line databases/resources cancercelllines; CVCL_C3C6
Encyclopedic resources Wikidata; Q114310516
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5