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Cellosaurus A549 SMAD4 -/- (CVCL_C3C4)

[Text version]
Cell line name A549 SMAD4 -/-
Accession CVCL_C3C4
Resource Identification Initiative To cite this cell line use: A549 SMAD4 -/- (RRID:CVCL_C3C4)
Comments Population: Caucasian.
Knockout cell: Method=ZFN; HGNC; 6770; SMAD4.
Transfected with: UniProtKB; Q9U6Y8; Discosoma sp. red fluorescent protein drFP583 (DsRed, RFP).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Web pages https://www.sigmaaldrich.com/catalog/product/sigma/clls1013
Cross-references
Cell line databases/resources cancercelllines; CVCL_C3C4
Encyclopedic resources Wikidata; Q114310531
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5