Cellosaurus logo
expasy logo

Cellosaurus SKOV3-GFP-HER2 RFP-EGFR (CVCL_C3C3)

[Text version]
Cell line name SKOV3-GFP-HER2 RFP-EGFR
Accession CVCL_C3C3
Resource Identification Initiative To cite this cell line use: SKOV3-GFP-HER2 RFP-EGFR (RRID:CVCL_C3C3)
Comments Population: Caucasian.
Characteristics: Edited by ZFN at the ERBB2 locus to insert a TagGFP2 construct at the C-terminus of the gene and at the EGFR locus to insert a TagRFP construct at the C-terminus of the gene (Sigma-Aldrich=CLL1143).
Genetic integration: Method=ZFN; Gene=FPbase; GJETS; TagGFP2 (Note=Green fluorescent protein derived from Aequorea macrodactyla GFP).
Genetic integration: Method=ZFN; Gene=FPbase; S4HC8; TagRFP (Note=Red fluorescent protein derived from eqFP578).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C3C2 (SKOV3-GFP-HER2)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Sigma-Aldrich; CLL1143
Cell line databases/resources cancercelllines; CVCL_C3C3
Encyclopedic resources Wikidata; Q114313034
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number7