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Cellosaurus Huh-7.5 STAT1 KO #1 (CVCL_C2UW)

[Text version]
Cell line name Huh-7.5 STAT1 KO #1
Accession CVCL_C2UW
Resource Identification Initiative To cite this cell line use: Huh-7.5 STAT1 KO #1 (RRID:CVCL_C2UW)
Comments Population: Japanese.
Knockout cell: Method=CRISPR/Cas9; HGNC; 11362; STAT1.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7927 (Huh-7.5)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=27929099; DOI=10.1038/srep38336; PMCID=PMC5144079
Yamauchi S., Takeuchi K., Chihara K., Honjoh C., Kato Y., Yoshiki H., Hotta H., Sada K.
STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-lambda but not by interferon-alpha.
Sci. Rep. 6:38336-38336(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C2UW
Encyclopedic resources Wikidata; Q114311675
Gene expression databases GEO; GSM2247743
GEO; GSM2247744
GEO; GSM2247745
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5