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Cellosaurus UPMD-1 (CVCL_C297)

[Text version]
Cell line name UPMD-1
Synonyms UPMD1; Uveal Primary Melanoma with Disomy-3 1
Accession CVCL_C297
Resource Identification Initiative To cite this cell line use: UPMD-1 (RRID:CVCL_C297)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 100 hours (PubMed=19212147).
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Sequence variations
  • Mutation; HGNC; 4379; GNA11; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000376002; Zygosity=Unspecified (PubMed=22236444).
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=22236444

Markers:
AmelogeninX
CSF1PO9,10
D3S135814,16
D5S81811,12
D7S82011,12
D13S31711,13
D16S53912
FGA21,22
TH019.3
TPOX11,12
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=19212147; DOI=10.1159/000201566
Nareyeck G., Zeschnigk M., Bornfeld N., Anastassiou G.
Novel cell lines derived by long-term culture of primary uveal melanomas.
Ophthalmologica 223:196-201(2009)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x
Griewank K.G., Yu X.-X., Khalili J., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Amaro A., Mirisola V., Angelini G., Musso A., Tosetti F.I., Esposito A.I., Perri P., Lanza F.B., Nasciuti F., Mosci C., Puzone R., Salvi S., Truini M., Poggi A., Pfeffer U.
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by Gefitinib and Cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C297
DepMap; ACH-002926
Encyclopedic resources Wikidata; Q54991702
Polymorphism and mutation databases Cosmic; 1628403
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number16