ID   UPMM-2
AC   CVCL_C294
SY   UPMM2; Uveal Primary Melanoma with Monosomy-3 2
DR   cancercelllines; CVCL_C294
DR   Cosmic; 1628400
DR   Kerafast; EDE002
DR   Wikidata; Q54991707
RX   PubMed=16750193;
RX   PubMed=19212147;
RX   PubMed=22236444;
RX   PubMed=23849826;
CC   Doubling time: 150 hours (PubMed=19212147).
CC   Karyotypic information: Monosomy of chromosome 3 (PubMed=16750193).
CC   Sequence variation: Mutation; HGNC; HGNC:4390; GNAQ; Simple; p.Gln209Leu (c.626A>T); ClinVar=VCV000375955; Zygosity=Unspecified (PubMed=22236444).
CC   Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
ST   Source(s): PubMed=22236444
ST   Amelogenin: X
ST   CSF1PO: 11,13
ST   D13S317: 9,12
ST   D16S539: 12
ST   D3S1358: 17
ST   D5S818: 10,11
ST   D7S820: 9
ST   FGA: 21.2,24
ST   TH01: 9,9.3
ST   TPOX: 9
ST   vWA: 16,18
DI   NCIt; C7712; Uveal melanoma
DI   ORDO; Orphanet_39044; Uveal melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 16
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RX   PubMed=16750193; DOI=10.1016/j.exer.2006.04.004;
RA   Nareyeck G., Zeschnigk M., Prescher G., Lohmann D.R., Anastassiou G.;
RT   "Establishment and characterization of two uveal melanoma cell lines
RT   derived from tumors with loss of one chromosome 3.";
RL   Exp. Eye Res. 83:858-864(2006).
//
RX   PubMed=19212147; DOI=10.1159/000201566;
RA   Nareyeck G., Zeschnigk M., Bornfeld N., Anastassiou G.;
RT   "Novel cell lines derived by long-term culture of primary uveal
RT   melanomas.";
RL   Ophthalmologica 223:196-201(2009).
//
RX   PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394;
RA   Griewank K.G., Yu X.-X., Khalili J.S., Sozen M.M., Stempke-Hale K.,
RA   Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.;
RT   "Genetic and molecular characterization of uveal melanoma cell
RT   lines.";
RL   Pigment Cell Melanoma Res. 25:182-187(2012).
//
RX   PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011;
RA   Amaro A., Mirisola V., Angelini G., Musso A., Tosetti F.I.,
RA   Esposito A.I., Perri P., Lanza F.B., Nasciuti F., Mosci C., Puzone R.,
RA   Salvi S., Truini M., Poggi A., Pfeffer U.;
RT   "Evidence of epidermal growth factor receptor expression in uveal
RT   melanoma: inhibition of epidermal growth factor-mediated signalling
RT   by gefitinib and cetuximab triggered antibody-dependent cellular
RT   cytotoxicity.";
RL   Eur. J. Cancer 49:3353-3365(2013).
//