ID   WM858
AC   CVCL_C283
SY   WM-858; WM 858; Wm858; WML-858
DR   cancercelllines; CVCL_C283
DR   Cosmic; 1155558
DR   GEO; GSM109045
DR   GEO; GSM186497
DR   GEO; GSM186498
DR   GEO; GSM952588
DR   Progenetix; CVCL_C283
DR   Rockland; WM858-01-0001
DR   Wikidata; Q54994326
RX   PubMed=2253310;
RX   PubMed=3856042;
RX   PubMed=4053039;
RX   PubMed=16827748;
RX   PubMed=18632627;
WW   https://www.wistar.org/our-scientists/meenhard-herlyn
CC   Part of: Wistar Institute melanoma cell line collection.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=16827748; Wistar).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Right axillary lymph node; UBERON=UBERON_0001097.
ST   Source(s): Wistar
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 8,12
ST   D18S51: 14
ST   D19S433: 13,15
ST   D21S11: 29,32.2
ST   D2S1338: 22,23
ST   D3S1358: 17
ST   D5S818: 10,12
ST   D7S820: 9,10
ST   D8S1179: 12,13
ST   FGA: 20,23
ST   TH01: 6,8
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_L030 ! WM740V
OI   CVCL_C284 ! WM873-1
OI   CVCL_C285 ! WM873-2
OI   CVCL_C286 ! WM873-3
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 22
//
RX   PubMed=2253310; DOI=10.1007/BF00046337;
RA   Herlyn M.;
RT   "Human melanoma: development and progression.";
RL   Cancer Metastasis Rev. 9:101-112(1990).
//
RX   PubMed=3856042; DOI=10.1093/jnci/74.2.283;
RA   Herlyn M., Balaban G.B., Bennicelli J.L., Guerry D. IV, Halaban R.,
RA   Herlyn D., Elder D.E., Maul G.G., Steplewski Z., Nowell P.C.,
RA   Clark W.H. Jr., Koprowski H.;
RT   "Primary melanoma cells of the vertical growth phase: similarities to
RT   metastatic cells.";
RL   J. Natl. Cancer Inst. 74:283-289(1985).
//
RX   PubMed=4053039;
RA   Herlyn M., Thurin J., Balaban G.B., Bennicelli J.L., Herlyn D.,
RA   Elder D.E., Bondi E., Guerry D. IV, Nowell P.C., Clark W.H. Jr.,
RA   Koprowski H.;
RT   "Characteristics of cultured human melanocytes isolated from different
RT   stages of tumor progression.";
RL   Cancer Res. 45:5670-5676(1985).
//
RX   PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x;
RA   Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R.,
RA   Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D.,
RA   Dummer R.;
RT   "Metastatic potential of melanomas defined by specific gene expression
RT   profiles with no BRAF signature.";
RL   Pigment Cell Res. 19:290-302(2006).
//
RX   PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235;
RA   Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R.,
RA   Muthusamy V., King A.J., Flaherty K.T., Bosenberg M.W., Herlyn M.,
RA   Nathanson K.L.;
RT   "Identification of a novel subgroup of melanomas with
RT   KIT/cyclin-dependent kinase-4 overexpression.";
RL   Cancer Res. 68:5743-5752(2008).
//