ID   WM858
AC   CVCL_C283
SY   WM-858; WM 858; Wm858; WML-858
DR   cancercelllines; CVCL_C283
DR   Cosmic; 1155558
DR   GEO; GSM109045
DR   GEO; GSM186497
DR   GEO; GSM186498
DR   GEO; GSM952588
DR   Progenetix; CVCL_C283
DR   Rockland; WM858-01-0001
DR   Wikidata; Q54994326
RX   PubMed=2253310;
RX   PubMed=3856042;
RX   PubMed=4053039;
RX   PubMed=16827748;
RX   PubMed=18632627;
WW   Info; Wistar; -; https://www.wistar.org/our-scientists/meenhard-herlyn
CC   Part of: Wistar Institute melanoma cell line collection.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=16827748; Wistar).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Right axillary lymph node; UBERON=UBERON_0001097.
ST   Source(s): Wistar
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 8,12
ST   D18S51: 14
ST   D19S433: 13,15
ST   D21S11: 29,32.2
ST   D2S1338: 22,23
ST   D3S1358: 17
ST   D5S818: 10,12
ST   D7S820: 9,10
ST   D8S1179: 12,13
ST   FGA: 20,23
ST   TH01: 6,8
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_L030 ! WM740V
OI   CVCL_C284 ! WM873-1
OI   CVCL_C285 ! WM873-2
OI   CVCL_C286 ! WM873-3
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 24
//
RX   PubMed=2253310; DOI=10.1007/BF00046337;
RA   Herlyn, Meenhard
RT   "Human melanoma: development and progression.";
RL   Cancer Metastasis Rev. 9:101-112(1990).
//
RX   PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688;
RA   Smalley, Keiran S.M.
RA   Contractor, Rooha
RA   Nguyen, Thiennga K.
RA   Xiao, Min
RA   Edwards, Robin
RA   Muthusamy, Viswanathan
RA   King, Alastair J.
RA   Flaherty, Keith Thomas
RA   Bosenberg, Marcus W.
RA   Herlyn, Meenhard
RA   Nathanson, Katherine L.
RT   "Identification of a novel subgroup of melanomas with
RT   KIT/cyclin-dependent kinase-4 overexpression.";
RL   Cancer Res. 68:5743-5752(2008).
//
RX   PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x;
RA   Hoek, Keith S.
RA   Schlegel, Natalie C.
RA   Brafford, Patricia
RA   Sucker, Antje
RA   Ugurel, Selma
RA   Kumar, Rajiv
RA   Weber, Barbara L.
RA   Nathanson, Katherine L.
RA   Phillips, Donald J.
RA   Herlyn, Meenhard
RA   Schadendorf, Dirk
RA   Dummer, Reinhard
RT   "Metastatic potential of melanomas defined by specific gene expression
RT   profiles with no BRAF signature.";
RL   Pigment Cell Res. 19:290-302(2006).
//
RX   PubMed=4053039;
RA   Herlyn, Meenhard
RA   Thurin, Jan
RA   Balaban-Malenbaum, Gloria Brady
RA   Bennicelli, Jeannette L.
RA   Herlyn, Dorothee
RA   Elder, David E.
RA   Bondi, Edward
RA   Guerry, DuPont 4th
RA   Nowell, Peter Carey
RA   Clark, Wallace H. Jr.
RA   Koprowski, Hilary
RT   "Characteristics of cultured human melanocytes isolated from different
RT   stages of tumor progression.";
RL   Cancer Res. 45:5670-5676(1985).
//
RX   PubMed=3856042; DOI=10.1093/jnci/74.2.283;
RA   Herlyn, Meenhard
RA   Balaban-Malenbaum, Gloria Brady
RA   Bennicelli, Jeannette L.
RA   Guerry, DuPont 4th
RA   Halaban, Ruth
RA   Herlyn, Dorothee
RA   Elder, David E.
RA   Maul, Gerd G.
RA   Steplewski, Zenon
RA   Nowell, Peter Carey
RA   Clark, Wallace H. Jr.
RA   Koprowski, Hilary
RT   "Primary melanoma cells of the vertical growth phase: similarities to
RT   metastatic cells.";
RL   J. Natl. Cancer Inst. 74:283-289(1985).
//