ID   WM853-2
AC   CVCL_C282
SY   WM-853-2; WM 853-2; WML 853-2
DR   cancercelllines; CVCL_C282
DR   Rockland; WM853-2-01-0001
DR   Wikidata; Q54994324
RX   PubMed=2253310;
RX   PubMed=4053039;
WW   https://www.wistar.org/our-scientists/meenhard-herlyn
CC   Part of: Wistar Institute melanoma cell line collection.
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (Wistar).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (Wistar).
CC   Omics: Transcriptome analysis by microarray.
CC   Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: D8S1179: 11->11,14 and FGA: 22->20,22.
CC   Derived from site: In situ; Back, skin; UBERON=UBERON_0001068.
ST   Source(s): Wistar
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 10,13
ST   D18S51: 14
ST   D19S433: 14,15
ST   D21S11: 29,30
ST   D2S1338: 17,24
ST   D3S1358: 16,17
ST   D5S818: 11,13
ST   D7S820: 10,12
ST   D8S1179: 11,14
ST   FGA: 20,22
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   71Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 18
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RX   PubMed=2253310; DOI=10.1007/BF00046337;
RA   Herlyn M.;
RT   "Human melanoma: development and progression.";
RL   Cancer Metastasis Rev. 9:101-112(1990).
//
RX   PubMed=4053039;
RA   Herlyn M., Thurin J., Balaban G.B., Bennicelli J.L., Herlyn D.,
RA   Elder D.E., Bondi E., Guerry D. IV, Nowell P.C., Clark W.H. Jr.,
RA   Koprowski H.;
RT   "Characteristics of cultured human melanocytes isolated from different
RT   stages of tumor progression.";
RL   Cancer Res. 45:5670-5676(1985).
//