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Cellosaurus WM139 (CVCL_C266)

[Text version]
Cell line name WM139
Synonyms WM-139; WM 139; EST71
Accession CVCL_C266
Resource Identification Initiative To cite this cell line use: WM139 (RRID:CVCL_C266)
Comments Part of: Wistar Institute melanoma cell line collection.
Omics: Array-based CGH.
Sequence variations
  • Gene deletion; HGNC; 9588; PTEN; Zygosity=Homozygous (PubMed=17260012).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Val82fs (c.243_244ins19) (p.Arg96fs, c.286_287ins19); Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*32:01,32:01
HLA-BB*14:01,14:01
HLA-CC*08:02,08:02
Class II
HLA-DPDPB1*02:01:02,02:01:02
HLA-DQDQB1*02:01,02:01
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ESTDAB

Markers:
AmelogeninX
CSF1PO12
D3S135814,17
D5S8189,11
D7S8209,11
D13S3179
FGA20,25
TH017,9
TPOX8,11
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello F., Dodi I.A., Lopez Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=19340423; DOI=10.1007/s00262-009-0701-z
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C266
ESTDAB; ESTDAB-071
Encyclopedic resources Wikidata; Q54994174
Gene expression databases GEO; GSM156024
Polymorphism and mutation databases Cosmic; 1047651
Cosmic; 2163801
IARC_TP53; 26078
Progenetix; CVCL_C266
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number20