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Cellosaurus SIGi001-A-20 (CVCL_C1U6)

[Text version]
Cell line name SIGi001-A-20
Synonyms Sigma-SOX9; KULi002-A-20
Accession CVCL_C1U6
Resource Identification Initiative To cite this cell line use: SIGi001-A-20 (RRID:CVCL_C1U6)
Comments From: KU Leuven; Leuven; Belgium.
Population: Caucasian.
Characteristics: Using ZFN a cassette containing a Tet-ON SOX9 construct framed by FRT and FRT3 sites was introduced in the AAVS1 safe harbor locus (PubMed=33982246).
Genetic integration: Method=ZFN; Gene=HGNC; 11204; SOX9.
Genetic integration: Method=ZFN; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=ZFN; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Genetic integration: Method=ZFN; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_EE38 (SIGi001-A)
Sex of cell Female
Age at sampling 24Y
Category Induced pluripotent stem cell
Publications

PubMed=33982246; DOI=10.1007/s12015-021-10179-x; PMCID=PMC8553725
Neyrinck K., Van Den Daele J., Vervliet T., De Smedt J., Wierda K., Nijs M., Vanbokhoven T., D'hondt A., Planque M., Fendt S.-M., Shih P.-Y., Seibt F., Almenar J.P., Kreir M., Kumar D., Broccoli V., Bultynck G., Ebneth A., Cabrera-Socorro A., Verfaillie C.M.
SOX9-induced generation of functional astrocytes supporting neuronal maturation in an all-human system.
Stem Cell Rev. Rep. 17:1855-1873(2021)

Cross-references
Cell line databases/resources hPSCreg; SIGi001-A-20
Biological sample resources BioSamples; SAMEA6703233
Encyclopedic resources Wikidata; Q114313016
Entry history
Entry creation22-Sep-2022
Last entry update10-Sep-2024
Version number6