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Cellosaurus SJ-HGGX6c (CVCL_C1NM)

[Text version]
Cell line name SJ-HGGX6c
Synonyms SJHGG009103_C8
Accession CVCL_C1NM
Resource Identification Initiative To cite this cell line use: SJ-HGGX6c (RRID:CVCL_C1NM)
Comments Characteristics: Derived from a patient-derived xenograft.
Doubling time: 5.6 days (PubMed=34215733).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 8DNLG; YFP (Note=EYFP, yellow fluorescent protein derived from GFP).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brain, cerebral cortex; UBERON=UBERON_0000956.
Sequence variations
  • Mutation; HGNC; HGNC:886; ATRX; Simple; p.Thr1582fs (c.4745delA); Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Gly35Arg (c.103G>A) (H3.3G34R); ClinVar=VCV000438766; Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:25311; H3C13; Simple; p.Ser88Pro (c.262T>C); Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:8803; PDGFRA; Simple; p.Asp583_Trp586del (c.1749_1760del); Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (PubMed=34215733).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 16-17Y
Category Cancer cell line
STR profile Source(s): PubMed=34215733

Markers:
AmelogeninX
CSF1PO12
D3S135816,18
D5S81811,12
D7S82010,14
D8S117910,15
D13S31712
D16S53912,13
D18S5112,16
D21S1132.2
FGA23,25
Penta D9,13
Penta E11,14
TH017,9.3
TPOX11
vWA14,15

Run an STR similarity search on this cell line
Web pages https://pbtp.stjude.cloud/sample-details/29960/baker/SJHGG009103/SJ-HGGX6/Cell%20Line
Publications

PubMed=34215733; DOI=10.1038/s41467-021-24168-8; PMCID=PMC8253809
He C., Xu K., Zhu X.-Y., Dunphy P.S., Gudenas B., Lin W.-W., Twarog N., Hover L.D., Kwon C.-H., Kasper L.H., Zhang J.-Y., Li X.-Y., Dalton J., Jonchere B., Mercer K.S., Currier D.G., Caufield W., Wang Y.-Z., Xie J., Broniscer A., Wetmore C., Upadhyaya S.A., Qaddoumi I., Klimo P., Boop F., Gajjar A., Zhang J.-H., Orr B.A., Robinson G.W., Monje M., Freeman B.B. 3rd, Roussel M.F., Northcott P.A., Chen T.-S., Rankovic Z., Wu G., Chiang J.C.-H., Tinkle C.L., Shelat A.A., Baker S.J.
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
Nat. Commun. 12:4089.1-4089.17(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1NM
Encyclopedic resources Wikidata; Q114313027
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number7