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Cellosaurus SJ-DIPGX7c (CVCL_C1NH)

[Text version]
Cell line name SJ-DIPGX7c
Synonyms SJHGG00101_C2
Accession CVCL_C1NH
Resource Identification Initiative To cite this cell line use: SJ-DIPGX7c (RRID:CVCL_C1NH)
Comments Characteristics: Derived from a patient-derived xenograft.
Doubling time: 6.1 days (PubMed=34215733).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
Sequence variations
  • Mutation; HGNC; 20893; BCOR; Simple; p.Thr200_Leu201fs (c.600_603delGCCA); Zygosity=Homozygous (PubMed=34215733).
  • Mutation; HGNC; 4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys176Tyr (c.527G>A); ClinVar=VCV000186451; Zygosity=Homozygous (PubMed=34215733).
Disease Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 17-18Y
Category Cancer cell line
STR profile Source(s): PubMed=34215733

Markers:
AmelogeninX
CSF1PO9
D3S135814,17
D5S81811
D7S8209,10
D8S117914,16
D13S31713
D16S53912
D18S5117
D21S1131,31.2
FGA22,23
Penta D8,11
Penta E10,12
TH017
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Web pages https://pbtp.stjude.cloud/sample-details/29956/baker/SJHGG000101/SJ-DIPGX7/Cell%20Line
Publications

PubMed=34215733; DOI=10.1038/s41467-021-24168-8; PMCID=PMC8253809
He C., Xu K., Zhu X.-Y., Dunphy P.S., Gudenas B., Lin W.-W., Twarog N., Hover L.D., Kwon C.-H., Kasper L.H., Zhang J.-Y., Li X.-Y., Dalton J., Jonchere B., Mercer K.S., Currier D.G., Caufield W., Wang Y.-Z., Xie J., Broniscer A., Wetmore C., Upadhyaya S.A., Qaddoumi I., Klimo P., Boop F., Gajjar A., Zhang J.-H., Orr B.A., Robinson G.W., Monje M., Freeman B.B. 3rd, Roussel M.F., Northcott P.A., Chen T.-S., Rankovic Z., Wu G., Chiang J.C.-H., Tinkle C.L., Shelat A.A., Baker S.J.
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
Nat. Commun. 12:4089.1-4089.17(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1NH
Encyclopedic resources Wikidata; Q114313022
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5