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Cellosaurus SJ-DIPGX37c (CVCL_C1NG)

[Text version]
Cell line name SJ-DIPGX37c
Synonyms SJHGG015756_C35
Accession CVCL_C1NG
Resource Identification Initiative To cite this cell line use: SJ-DIPGX37c (RRID:CVCL_C1NG)
Comments Characteristics: Derived from a patient-derived xenograft.
Doubling time: 9.0 days (PubMed=34215733).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
Sequence variations
  • Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Homozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Tyr452_Asn453Tyr (c.1356_1358delTAA); Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu513fs (c.1539dupT); Zygosity=Heterozygous (PubMed=34215733).
Disease Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 8-9Y
Category Cancer cell line
STR profile Source(s): PubMed=34215733

Markers:
AmelogeninX,Y
CSF1PO11
D3S135814,16
D5S81812,14
D7S8209,11
D8S117914
D13S31713
D16S53911
D18S5112,16
D21S1128,29
FGA21,22
Penta D11,12
Penta E7,17
TH019,9.3
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Web pages https://pbtp.stjude.cloud/sample-details/29966/baker/SJHGG015756/SJ-DIPGX37/Cell%20Line
Publications

PubMed=34215733; DOI=10.1038/s41467-021-24168-8; PMCID=PMC8253809
He C., Xu K., Zhu X.-Y., Dunphy P.S., Gudenas B., Lin W.-W., Twarog N., Hover L.D., Kwon C.-H., Kasper L.H., Zhang J.-Y., Li X.-Y., Dalton J., Jonchere B., Mercer K.S., Currier D.G., Caufield W., Wang Y.-Z., Xie J., Broniscer A., Wetmore C., Upadhyaya S.A., Qaddoumi I., Klimo P., Boop F., Gajjar A., Zhang J.-H., Orr B.A., Robinson G.W., Monje M., Freeman B.B. 3rd, Roussel M.F., Northcott P.A., Chen T.-S., Rankovic Z., Wu G., Chiang J.C.-H., Tinkle C.L., Shelat A.A., Baker S.J.
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
Nat. Commun. 12:4089.1-4089.17(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1NG
Encyclopedic resources Wikidata; Q114313021
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6