Cellosaurus cell line SJ-DIPGX29c (CVCL

Cellosaurus SJ-DIPGX29c (CVCL_C1NF)

[Text version]

Cell line name

SJ-DIPGX29c

Synonyms

SJHGG013322_C2

Accession

CVCL_C1NF

Resource Identification Initiative

To cite this cell line use: SJ-DIPGX29c (RRID:CVCL_C1NF)

Comments

Characteristics: Derived from a patient-derived xenograft.
Doubling time: 9.0 days (PubMed=34215733).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.

Sequence variations

Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Heterozygous (PubMed=34215733).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (PubMed=34215733).

Disease

Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

11-12Y

Category

Cancer cell line

STR profile

Source(s): PubMed=34215733

Markers:

Amelogenin	X
CSF1PO	10
D3S1358	15,17
D5S818	12,13
D7S820	10,12
D8S1179	12,13
D13S317	11,12
D16S539	9,11
D18S51	22
D21S11	29
FGA	24
Penta D	11
Penta E	12,16
TH01	9.3
TPOX	8,11
vWA	18

Web pages

https://pbtp.stjude.cloud/sample-details/29964/baker/SJHGG013322/SJ-DIPGX29/Cell%20Line

Publications

PubMed=34215733; DOI=10.1038/s41467-021-24168-8; PMCID=PMC8253809
He C., Xu K., Zhu X.-Y., Dunphy P.S., Gudenas B., Lin W.-W., Twarog N., Hover L.D., Kwon C.-H., Kasper L.H., Zhang J.-Y., Li X.-Y., Dalton J., Jonchere B., Mercer K.S., Currier D.G., Caufield W., Wang Y.-Z., Xie J., Broniscer A., Wetmore C., Upadhyaya S.A., Qaddoumi I., Klimo P., Boop F., Gajjar A., Zhang J.-H., Orr B.A., Robinson G.W., Monje M., Freeman B.B. 3rd, Roussel M.F., Northcott P.A., Chen T.-S., Rankovic Z., Wu G., Chiang J.C.-H., Tinkle C.L., Shelat A.A., Baker S.J.
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
Nat. Commun. 12:4089.1-4089.17(2021)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_C1NF

Encyclopedic resources

Wikidata; Q114313020

Gene expression databases

GEO; GSM4600831

Entry history

Entry creation

22-Sep-2022

Last entry update

19-Dec-2024

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