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Cellosaurus A2780veliR (CVCL_C1NE)

[Text version]
Cell line name A2780veliR
Accession CVCL_C1NE
Resource Identification Initiative To cite this cell line use: A2780veliR (RRID:CVCL_C1NE)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:62880; Veliparib (ABT-888).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=34445211; DOI=10.3390/ijms22168506; PMCID=PMC8395221
Dickson K.-A., Xie T., Evenhuis C., Ma Y., Marsh D.J.
PARP inhibitors display differential efficacy in models of BRCA mutant high-grade serous ovarian cancer.
Int. J. Mol. Sci. 22:8506.1-8506.14(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1NE
Encyclopedic resources Wikidata; Q114310504
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5