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Cellosaurus SNU-601 Ola-R (CVCL_C1NB)

[Text version]
Cell line name SNU-601 Ola-R
Synonyms SNU-601/olaparib-resistant; Olaparib-resistant SNU-601
Accession CVCL_C1NB
Resource Identification Initiative To cite this cell line use: SNU-601 Ola-R (RRID:CVCL_C1NB)
Comments Population: Korean.
Selected for resistance to: ChEBI; CHEBI:83766; Olaparib.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 18884; TDP1; Simple; p.Ala520Asp; Zygosity=Unspecified (PubMed=32028591).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Gastric signet ring cell adenocarcinoma (NCIt: C5250)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0101 (SNU-601)
Sex of cell Male
Age at sampling 34Y
Category Cancer cell line
Publications

PubMed=32028591; DOI=10.3390/cancers12020334; PMCID=PMC7072281
Kim J.W., Min A., Im S.-A., Jang H., Kim Y.J., Kim H.-J., Lee K.-H., Kim T.-Y., Lee K.W., Oh D.-Y., Kim J.-H., Bang Y.-J.
TDP1 and TOP1 modulation in olaparib-resistant cancer determines the efficacy of subsequent chemotherapy.
Cancers (Basel) 12:334.1-334.17(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1NB
Encyclopedic resources Wikidata; Q114313042
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5