ID   TT10728
AC   CVCL_C1MN
DR   cancercelllines; CVCL_C1MN
DR   Wikidata; Q114313133
RX   PubMed=29100338;
RX   PubMed=32229503;
RX   PubMed=34732238;
CC   Population: Chinese.
CC   Doubling time: 46.8 +- 0.4 hours (PubMed=29100338).
CC   Sequence variation: Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=29100338; PubMed=32229503; PubMed=34732238).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (PubMed=29100338; PubMed=32229503; PubMed=34732238).
CC   Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
ST   Source(s): PubMed=34732238
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,11
ST   D16S539: 12
ST   D21S11: 30
ST   D5S818: 10,11
ST   D7S820: 8,11
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 17,18
DI   NCIt; C94764; Diffuse intrinsic pontine glioma
DI   ORDO; Orphanet_497188; Diffuse intrinsic pontine glioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   7Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 6
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RX   PubMed=29100338; DOI=10.18632/oncotarget.19656; PMCID=PMC5652732;
RA   Xu C., Liu X.-Q., Geng Y.-B., Bai Q.-R., Pan C.-C., Sun Y., Chen X.,
RA   Yu H., Wu Y.-L., Zhang P., Wu W.-H., Wang Y., Wu Z., Zhang J.-T.,
RA   Wang Z.-H., Yang R., Lewis J., Bigner D.D., Zhao F.-P., He Y.-P., Yan H.,
RA   Shen Q., Zhang L.-W.;
RT   "Patient-derived DIPG cells preserve stem-like characteristics and
RT   generate orthotopic tumors.";
RL   Oncotarget 8:76644-76655(2017).
//
RX   PubMed=32229503; DOI=10.1158/1541-7786.MCR-19-0507;
RA   Wang Z.-H., Xu C., Diplas B.H., Moure C.J., Chen C.-P.J., Chen L.H.,
RA   Du C.-Z., Zhu H.-S., Greer P.K., Zhang L.-W., He Y.-P., Waitkus M.S.,
RA   Yan H.;
RT   "Targeting mutant PPM1D sensitizes diffuse intrinsic pontine glioma
RT   cells to the PARP inhibitor olaparib.";
RL   Mol. Cancer Res. 18:968-980(2020).
//
RX   PubMed=34732238; DOI=10.1186/s40478-021-01270-y; PMCID=PMC8565061;
RA   Xu C., Liu H., Pirozzi C.J., Chen L.H., Greer P.K., Diplas B.H.,
RA   Zhang L.-W., Waitkus M.S., He Y.-P., Yan H.;
RT   "TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are
RT   sensitive to a MDM2 antagonist.";
RL   Acta Neuropathol. Commun. 9:178.1-178.12(2021).
//