ID   ALL-VG
AC   CVCL_C1ME
DR   Wikidata; Q114310621
RX   PubMed=18656692;
RX   PubMed=28650474;
CC   Karyotypic information: 45,XY,der(1)t(1;9),der(9)t(9;13),-13,der(16)t(16;22) (PubMed=18656692).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1785; CDKN1B; Zygosity=Unspecified (PubMed=18656692).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Unspecified (PubMed=18656692).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Unspecified (PubMed=18656692).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:3495; ETV6; Name(s)=ETV6-ABL1 (PubMed=18656692; PubMed=28650474).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Proteome analysis by 2D-DE/MS.
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   30Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 5
//
RX   PubMed=18656692; DOI=10.1016/j.cancergencyto.2008.05.001;
RA   Baeumler J., Szuhai K., Falkenburg J.H.F., van Schie M.L.J., Ottmann O.G.,
RA   Nijmeijer B.A.;
RT   "Establishment and cytogenetic characterization of a human acute
RT   lymphoblastic leukemia cell line (ALL-VG) with ETV6/ABL1
RT   rearrangement.";
RL   Cancer Genet. Cytogenet. 185:37-42(2008).
//
RX   PubMed=28650474; DOI=10.1038/onc.2017.210; PMCID=PMC5666322;
RA   Zimmermannova O., Doktorova E., Stuchly J., Kanderova V.,
RA   Kuzilkova D., Strnad H., Starkova J., Alberich-Jorda M.,
RA   Falkenburg J.H.F., Trka J., Petrak J., Zuna J., Zaliova M.;
RT   "An activating mutation of GNB1 is associated with resistance to
RT   tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia.";
RL   Oncogene 36:5985-5994(2017).
//