ID   H446/VP
AC   CVCL_C1MD
DR   cancercelllines; CVCL_C1MD
DR   Wikidata; Q114311556
RX   CelloPub=CLPUB00716;
RX   PubMed=21163134;
CC   Population: Caucasian.
CC   Doubling time: 35.7 hours (CelloPub=CLPUB00716).
CC   Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
CC   Sequence variation: Gene fusion; HGNC; 6728; LY6H + HGNC; 9709; PVT1; Name(s)=PVT1-LY6H (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly154Val (c.461G>T); ClinVar=VCV000651769; Zygosity=Homozygous (from parent cell line).
CC   Omics: miRNA expression profiling.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1562 ! NCI-H446
SX   Male
AG   61Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 5
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RX   CelloPub=CLPUB00716;
RA   Zhang H.-J., Yan Y.-L., Zheng L.-F., Wan P.;
RT   "Establishment and characterization of an etoposide-resistant human
RT   small cell lung cancer cell line H446/VP.";
RL   Zhong Liu 24:233-236(2004).
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RX   PubMed=21163134; DOI=10.3760/cma.j.issn.0366-6999.2010.22.024;
RA   Wang Y.-L., Yan Y.-L., Zhou N.-J., Han S., Zhao J.-X., Cao C.-L.,
RA   Lu Y.-H.;
RT   "Mechanism of multidrug resistance of human small cell lung cancer
RT   cell line H446/VP.";
RL   Chin. Med. J. 123:3299-3303(2010).
//