ID   betaG 111/228
AC   CVCL_C1JL
SY   betaG111/228
DR   Wikidata; Q114310740
RX   PubMed=9166666;
CC   Characteristics: Transfected with both a pCMV8-INS-IRES-Neo and a pCMV8-INS-IRES-PuroR constructs. Expresses 60 times more insulin than the grand-parent cell line (PubMed=9166666).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: NEDH; RS=RS:0000603.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_C1JK ! betaG 18/3E1
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 6
//
RX   PubMed=9166666; DOI=10.2337/diab.46.6.958;
RA   Clark S.A., Quaade C., Constandy H., Hansen P., Halban P.A., Ferber S.,
RA   Newgard C.B., Normington K.;
RT   "Novel insulinoma cell lines produced by iterative engineering of
RT   GLUT2, glucokinase, and human insulin expression.";
RL   Diabetes 46:958-967(1997).
//