ID   DOS16
AC   CVCL_C1HQ
SY   DOS-16; LMS-LFS
DR   cancercelllines; CVCL_C1HQ
DR   Wikidata; Q114311323
RX   CelloPub=CLPUB00712;
RX   DOI=10.26190/unsworks/20387;
RX   PubMed=19935656;
CC   Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
CC   Doubling time: 44 hours (DOI=10.26190/unsworks/20387).
CC   Karyotypic information: Near triploid karyotype (DOI=10.26190/unsworks/20387).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Heterozygous (DOI=10.26190/unsworks/20387).
CC   Miscellaneous: STR profile from personal communication of MacKenzie, Karen L.
CC   Derived from site: Metastatic; Retroperitoneal space; UBERON=UBERON_0003693.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 11,12
ST   D16S539: 12
ST   D18S51: 14
ST   D21S11: 30,32.2
ST   D3S1358: 15,16
ST   D5S818: 12,13
ST   D7S820: 9,11
ST   D8S1179: 8,14
ST   FGA: 21,23
ST   Penta D: 11
ST   Penta E: 7,13
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C3476; Li-Fraumeni syndrome
DI   NCIt; C27904; Retroperitoneal leiomyosarcoma
DI   ORDO; Orphanet_524; Li-Fraumeni syndrome
DI   ORDO; Orphanet_64720; Leiomyosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   37Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 10-09-24; Version: 6
//
RX   CelloPub=CLPUB00712;
RA   Henson J.D.;
RT   "The role of alternative lengthening of telomeres in human cancer.";
RL   Thesis PhD (2006); University of Sydney; Sydney; Australia.
//
RX   DOI=10.26190/unsworks/20387;
RA   Das Gupta R.;
RT   "Gene profiling in soft tissue sarcoma: predictive value of EGFR in
RT   sarcoma tumour progression and survival.";
RL   Thesis PhD (2007); University of New South Wales; Sydney; Australia.
//
RX   PubMed=19935656; DOI=10.1038/nbt.1587;
RA   Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M.,
RA   Pickett H.A., Reddel R.R.;
RT   "DNA C-circles are specific and quantifiable markers of
RT   alternative-lengthening-of-telomeres activity.";
RL   Nat. Biotechnol. 27:1181-1185(2009).
//