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Cellosaurus TAT2SF T4-B (CVCL_C1HL)

[Text version]
Cell line name TAT2SF T4-B
Synonyms T4-B subclone
Accession CVCL_C1HL
Resource Identification Initiative To cite this cell line use: TAT2SF T4-B (RRID:CVCL_C1HL)
Comments Characteristics: Transfected with a pSXneo-1.6-T2AG3 plasmid that contains 1.6 kb of telomeric repeat sequences (PubMed=9357546).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVori-).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Phe1774Lysfs*17 (c.5320_5326del) (c.5320del7); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 795; ATM; Simple; p.Trp2769Ter (c.8307G>A); ClinVar=VCV000189104; Zygosity=Heterozygous (from parent cell line).
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_F611 (TAT2SF)
Sex of cell Female
Category Transformed cell line
Publications

PubMed=9357546; DOI=10.1016/S0027-5107(97)00119-x
Sprung C.N., Bryan T.M., Reddel R.R., Murnane J.P.
Normal telomere maintenance in immortal ataxia telangiectasia cell lines.
Mutat. Res. 379:177-184(1997)

Cross-references
Encyclopedic resources Wikidata; Q114313096
Entry history
Entry creation22-Sep-2022
Last entry update10-Sep-2024
Version number6