Cellosaurus cell line COH-THL1 (CVCL

Cellosaurus COH-THL1 (CVCL_C1GM)

[Text version]

Cell line name

COH-THL1

Synonyms

City Of Hope-Triple Hit Lymphoma 1

Accession

CVCL_C1GM

Resource Identification Initiative

To cite this cell line use: COH-THL1 (RRID:CVCL_C1GM)

Comments

Characteristics: Has chromosomal translocation of the MYC, BCL2 and BCL6 genes.
Doubling time: 27 hours (PubMed=35687491).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Gene fusion; HGNC; HGNC:990; BCL2 + HGNC; HGNC:5477; IGH; Name(s)=IGH-BCL2 (PubMed=35687491).
Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (PubMed=35687491).

Disease

High grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements (NCIt: C131913)
High grade B-cell lymphoma with MYC and/or BCL2 and/or BCL6 rearrangement (ORDO: Orphanet_480541)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

78Y

Category

Cancer cell line

STR profile

Source(s): PubMed=35687491

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D5S818	12,13
D7S820	10,11
D13S317	13
D16S539	11
D21S11	28,32.2
TH01	6,9
TPOX	8
vWA	16,17

Publications

PubMed=35687491; DOI=10.1182/bloodadvances.2021006709; PMCID=PMC9631616
Zhang J.-B., Wang T.-T., Shetty K., Alkan S., Xu S.-L., Gong Q., Liu X.-X., Li Y.-P., Hu Z.-S., Huang W.-D., Wendel H.-G., Herrera A.F., Pillai R.K., Song J.Y., Chan W.-C.
Genetic characterization and drug sensitivity study of newly derived HGBL double/triple-hit lymphoma cell lines.
Blood Adv. 6:5067-5071(2022)

Cross-references

Encyclopedic resources

Wikidata; Q114310996

Entry history

Entry creation

22-Sep-2022

Last entry update

19-Dec-2024

Version number