Cellosaurus HEK293T Tet-off TauRD (CVCL_C1CS)
| Cell line name | HEK293T Tet-off TauRD |
|---|---|
| Synonyms | Tet-TauRD |
| Accession | CVCL_C1CS |
| Resource Identification Initiative | To cite this cell line use: HEK293T Tet-off TauRD (RRID:CVCL_C1CS) |
| Comments | Characteristics: Expresses the repeat domain of Tau/MAPT with a C-terminal Myc-Tag under the control of a Tet-regulated promoter (PubMed=36732333). Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16. Genetic integration: Method=Transfection; Gene=HGNC; 6893; MAPT (Note=Repeat domain with p.Pro301Leu and p.Val337Met). Genetic integration: Method=Transfection; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del). Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; B.cereus Bsr. Genetic integration: Method=Transfection; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR. Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen. Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 28285; Adenovirus 5. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA). Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113. |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0063 (HEK293T) |
| Sex of cell | Female |
| Age at sampling | Fetus |
| Category | Transformed cell line |
| Publications | PubMed=36732333; DOI=10.1038/s41467-023-36058-2; PMCID=PMC9894937 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q114311581 |
| Entry history | |
| Entry creation | 22-Sep-2022 |
| Last entry update | 10-Sep-2024 |
| Version number | 7 |