ID   U251-NF-kappaB-GFP-Luc-A1
AC   CVCL_C1CP
DR   cancercelllines; CVCL_C1CP
DR   Wikidata; Q114313145
RX   PubMed=28790798;
CC   Population: Caucasian.
CC   Characteristics: Transduced with a construct containing a fused GFP-Luc protein expressed under the control of a promoter containing multiple copies of the NF-kappaB response element.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0021 ! U-251MG
SX   Male
AG   75Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 5
//
RX   PubMed=28790798; DOI=10.1155/2017/6209865;
RA   Zeuner M.-T., Vallance T., Vaiyapuri S., Cottrell G.S., Widera D.;
RT   "Development and characterisation of a novel NF-kappaB reporter cell
RT   line for investigation of neuroinflammation.";
RL   Mediators Inflamm. 2017:6209865.1-6209865.10(2017).
//