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Cellosaurus BL-49 (CVCL_C150)

[Text version]
Cell line name BL-49
Synonyms BL49; BL 49; BL 049; IARC/BL49; IARC/BL 49; IARC-BL49; IARC BL49; IARC-BL-49; IARC BL 49
Accession CVCL_C150
Resource Identification Initiative To cite this cell line use: BL-49 (RRID:CVCL_C150)
Comments From: International Agency of Research on Cancer (IARC); Lyon; France.
Population: Caucasian.
Virology: EBV-negative.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys176Tyr (c.527G>A); ClinVar=VCV000186451; Zygosity=Unspecified (PubMed=2052620).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (PubMed=2052620).
Disease Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_IV15 ! BL-50
CVCL_VQ26 ! IARC-208
Sex of cell Male
Age at sampling 3Y
Category Cancer cell line
Publications

PubMed=6090749; DOI=10.1093/jnci/73.4.835
Philip I., Philip T., Favrot M.-C., Vuillaume M., Fontaniere B., Chamard D., Lenoir G.M.
Establishment of lymphomatous cell lines from bone marrow samples from patients with Burkitt's lymphoma.
J. Natl. Cancer Inst. 73:835-840(1984)

PubMed=6592381; DOI=10.1093/jnci/73.4.841
Favrot M.-C., Philip I., Philip T., Portoukalian J., Dore J.-F., Lenoir G.M.
Distinct reactivity of Burkitt's lymphoma cell lines with eight monoclonal antibodies correlated with the ethnic origin.
J. Natl. Cancer Inst. 73:841-847(1984)

PubMed=3905596
Favrot M.-C., Philip I., Philip T., Cabrillat H., Pinatel C., Dore J.-F., Lenoir G.M.
Immunophenotypic classification of 28 Burkitt cell lines with monoclonal antibodies and reagent selection for bone-marrow purging.
IARC Sci. Publ. 60:447-452(1985)

PubMed=3934070
Lenoir G.M., Vuillaume M., Bonnardel C.
The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma.
IARC Sci. Publ. 60:309-318(1985)

PubMed=3026973; DOI=10.1002/ijc.2910390215
Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Int. J. Cancer 39:211-218(1987)

PubMed=3027441; DOI=10.1093/jnci/78.2.235
Cohen J.H.M., Revillard J.-P., Magaud J.-P., Lenoir G.M., Vuillaume M., Manel A.-M., Vincent C., Bryon P.-A.
B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation.
J. Natl. Cancer Inst. 78:235-242(1987)

PubMed=2052620; DOI=10.1073/pnas.88.12.5413; PMCID=PMC51883
Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A., Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=11793449; DOI=10.1002/gcc.10022
Sobol H., Benziane A., Kerangueven F., Yin L., Noguchi T., Pauly S., Eisinger F., Longy M., Romeo G., Lenoir G.M., Birnbaum D.
Genome-wide search for loss of heterozygosity in Burkitt lymphoma cell lines.
Genes Chromosomes Cancer 33:217-224(2002)

PubMed=24590883; DOI=10.1002/gcc.22161
Murga Penas E.-M., Schilling G., Behrmann P., Klokow M., Vettorazzi E., Bokemeyer C., Dierlamm J.
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C150
Encyclopedic resources Wikidata; Q54797208
Polymorphism and mutation databases Cosmic; 931120
IARC_TP53; 139
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number20