ID   BL-37
AC   CVCL_C147
SY   BL37; BL 37; BL 037; IARC/BL37; IARC/BL 37; IARC-BL37; IARC BL37; IARC BL 37
DR   cancercelllines; CVCL_C147
DR   Cosmic; 931119
DR   Cosmic; 2804866
DR   DSMZ; ACC-918
DR   DSMZCellDive; ACC-918
DR   IARC_TP53; 136
DR   Wikidata; Q54797148
RX   PubMed=1915267;
RX   PubMed=2052620;
RX   PubMed=2898508;
RX   PubMed=2985508;
RX   PubMed=3027441;
RX   PubMed=3035497;
RX   PubMed=3934070;
RX   PubMed=6087353;
RX   PubMed=6090749;
RX   PubMed=6422306;
RX   PubMed=8108117;
RX   PubMed=9473234;
RX   PubMed=11793449;
RX   PubMed=25787276;
CC   From: International Agency of Research on Cancer (IARC); Lyon; France.
CC   Population: Caucasian; French.
CC   Virology: Contains a complete EBV genome (strain BL37) which has been sequenced (PubMed=25787276).
CC   Doubling time: ~50-60 hours (DSMZ=ACC-918).
CC   Sequence variation: Gene fusion; HGNC; HGNC:5853; IGL + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGL (PubMed=6422306).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Ile (c.711G>T); ClinVar=VCV000634770; Zygosity=Unspecified (PubMed=1915267; PubMed=2052620).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): DSMZ=ACC-918
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13
ST   D13S317: 11,12
ST   D16S539: 11,12
ST   D18S51: 9,18
ST   D19S433: 14,15
ST   D21S11: 30,32.2
ST   D2S1338: 19,24
ST   D3S1358: 14,15
ST   D5S818: 11
ST   D7S820: 10,12
ST   D8S1179: 13,14
ST   FGA: 21,25
ST   Penta D: 9,12
ST   Penta E: 6,15
ST   TH01: 8,9
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_VQ32 ! BL-39
OI   CVCL_IV05 ! IARC-176A
OI   CVCL_A2XI ! IARC-176B
OI   CVCL_VQ22 ! IARC-303A
OI   CVCL_A2XH ! IARC-303B
SX   Male
AG   3Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 22
//
RX   PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x; PMCID=PMC452998;
RA   Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.;
RT   "p53 is frequently mutated in Burkitt's lymphoma cell lines.";
RL   EMBO J. 10:2879-2887(1991).
//
RX   PubMed=2052620; DOI=10.1073/pnas.88.12.5413; PMCID=PMC51883;
RA   Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A.,
RA   Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.;
RT   "p53 mutations in human lymphoid malignancies: association with
RT   Burkitt lymphoma and chronic lymphocytic leukemia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991).
//
RX   PubMed=2898508; DOI=10.1084/jem.167.6.1811; PMCID=PMC2189677;
RA   Gregory C.D., Murray R.J., Edwards C.F., Rickinson A.B.;
RT   "Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in
RT   Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell
RT   escape from virus-specific T cell surveillance.";
RL   J. Exp. Med. 167:1811-1824(1988).
//
RX   PubMed=2985508; DOI=10.1002/ijc.2910350404;
RA   Rowe M., Rooney C.M., Rickinson A.B., Lenoir G.M., Rupani H.,
RA   Moss D.J., Stein H., Epstein M.A.;
RT   "Distinctions between endemic and sporadic forms of Epstein-Barr
RT   virus-positive Burkitt's lymphoma.";
RL   Int. J. Cancer 35:435-441(1985).
//
RX   PubMed=3027441; DOI=10.1093/jnci/78.2.235;
RA   Cohen J.H.M., Revillard J.-P., Magaud J.-P., Lenoir G.M., Vuillaume M.,
RA   Manel A.-M., Vincent C., Bryon P.-A.;
RT   "B-cell maturation stages of Burkitt's lymphoma cell lines according
RT   to Epstein-Barr virus status and type of chromosome translocation.";
RL   J. Natl. Cancer Inst. 78:235-242(1987).
//
RX   PubMed=3035497; DOI=10.1093/nar/15.11.4553; PMCID=PMC340879;
RA   Szajnert M.-F., Saule S., Bornkamm G.-W., Wajcman H., Lenoir G.M.,
RA   Kaplan J.-C.;
RT   "Clustered somatic mutations in and around first exon of
RT   non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation.";
RL   Nucleic Acids Res. 15:4553-4565(1987).
//
RX   PubMed=3934070;
RA   Lenoir G.M., Vuillaume M., Bonnardel C.;
RT   "The use of lymphomatous and lymphoblastoid cell lines in the study of
RT   Burkitt's lymphoma.";
RL   IARC Sci. Publ. 60:309-318(1985).
//
RX   PubMed=6087353; DOI=10.1073/pnas.81.15.4930; PMCID=PMC391606;
RA   Bornkamm G.-W., von Knebel-Doeberitz M., Lenoir G.M.;
RT   "No evidence for differences in the Epstein-Barr virus genome carried
RT   in Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from
RT   the same patients.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:4930-4934(1984).
//
RX   PubMed=6090749; DOI=10.1093/jnci/73.4.835;
RA   Philip I., Philip T., Favrot M.-C., Vuillaume M., Fontaniere B.,
RA   Chamard D., Lenoir G.M.;
RT   "Establishment of lymphomatous cell lines from bone marrow samples
RT   from patients with Burkitt's lymphoma.";
RL   J. Natl. Cancer Inst. 73:835-840(1984).
//
RX   PubMed=6422306; DOI=10.1038/307752a0;
RA   Hollis G.F., Mitchell K.F., Battey J., Potter H., Taub R.,
RA   Lenoir G.M., Leder P.;
RT   "A variant translocation places the lambda immunoglobulin genes 3' to
RT   the c-myc oncogene in Burkitt's lymphoma.";
RL   Nature 307:752-755(1984).
//
RX   PubMed=8108117;
RA   Albert T., Urlbauer B., Kohlhuber F., Hammersen B., Eick D.;
RT   "Ongoing mutations in the N-terminal domain of c-Myc affect
RT   transactivation in Burkitt's lymphoma cell lines.";
RL   Oncogene 9:759-763(1994).
//
RX   PubMed=9473234; DOI=10.1182/blood.V91.5.1680;
RA   Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.;
RT   "p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a
RT   mRNA and protein expression in Burkitt's lymphoma.";
RL   Blood 91:1680-1687(1998).
//
RX   PubMed=11793449; DOI=10.1002/gcc.10022;
RA   Sobol H., Benziane A., Kerangueven F., Yin L., Noguchi T., Pauly S.,
RA   Eisinger F., Longy M., Romeo G., Lenoir G.M., Birnbaum D.;
RT   "Genome-wide search for loss of heterozygosity in Burkitt lymphoma
RT   cell lines.";
RL   Genes Chromosomes Cancer 33:217-224(2002).
//
RX   PubMed=25787276; DOI=10.1128/JVI.03614-14; PMCID=PMC4442510;
RA   Palser A.L., Grayson N.E., White R.E., Corton C., Correia S.,
RA   Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G.,
RA   Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.;
RT   "Genome diversity of Epstein-Barr virus from multiple tumor types and
RT   normal infection.";
RL   J. Virol. 89:5222-5237(2015).
//