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Cellosaurus SKH1 [Human leukemia] (CVCL_C124)

[Text version]
Cell line name SKH1 [Human leukemia]
Synonyms SKH-1
Accession CVCL_C124
Resource Identification Initiative To cite this cell line use: SKH1 [Human leukemia] (RRID:CVCL_C124)
Comments Population: Japanese.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=8313895; PubMed=10576511).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=8313895; DOI=10.1002/j.1460-2075.1994.tb06288.x; PMCID=PMC394839
Mitani K., Ogawa S., Tanaka T.U., Miyoshi H., Kurokawa M., Mano H., Yazaki Y., Ohki M., Hirai H.
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.
EMBO J. 13:504-510(1994)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15156182; DOI=10.1038/sj.onc.1207777
Mitani K.
Molecular mechanisms of leukemogenesis by AML1/EVI-1.
Oncogene 23:4263-4269(2004)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

Cross-references
Encyclopedic resources Wikidata; Q54954739
Polymorphism and mutation databases Cosmic; 919117
Cosmic; 947370
Cosmic; 1012118
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number13