ID   BEL-A BSG KO
AC   CVCL_C0XA
SY   Basigin KO BEL-A
DR   Wikidata; Q114310731
RX   CelloPub=CLPUB00710;
RX   PubMed=31444345;
CC   Group: Malaria research cell line.
CC   Characteristics: Induced differentiated reticulocytes are completely refractory to invasion by Plasmodium falciparum (PubMed=31444345).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 1116; BSG.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Mononuclear cell; CL=CL_0000842.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C0X7 ! BEL-A2 clone 79
SX   Sex unspecified
AG   Adult
CA   Transformed cell line
DT   Created: 22-09-22; Last updated: 10-09-24; Version: 7
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RX   CelloPub=CLPUB00710;
RA   Hawksworth J.S.;
RT   "CRISPR-Cas9 gene editing in an immortalized erythroid cell line for
RT   production of engineered red blood cells.";
RL   Thesis PhD (2019); University of Bristol; Bristol; United Kingdom.
//
RX   PubMed=31444345; DOI=10.1038/s41467-019-11790-w; PMCID=PMC6707200;
RA   Satchwell T.J., Wright K.E., Haydn-Smith K.L., Sanchez-Roman Teran F.,
RA   Moura P.L., Hawksworth J.S., Frayne J., Toye A.M., Baum J.;
RT   "Genetic manipulation of cell line derived reticulocytes enables
RT   dissection of host malaria invasion requirements.";
RL   Nat. Commun. 10:3806.1-3806.9(2019).
//