ID   HepG2 PXR-CYP3A4 clone 8
AC   CVCL_C0V9
DR   cancercelllines; CVCL_C0V9
DR   Wikidata; Q112929724
RX   PubMed=33896369;
CC   Population: Caucasian.
CC   Characteristics: Transfected with both pcDNA3.1-hPXR and pGLuc-CYP3A4.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 2637; CYP3A4.
CC   Transfected with: HGNC; 7968; NR1I2.
CC   Transfected with: UniProtKB; Q9BLZ2; Gaussia princeps luciferase.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 05-10-23; Version: 5
//
RX   PubMed=33896369; DOI=10.1080/00498254.2021.1918800;
RA   Li H., Wang Y.-G., Ma Z.-C., Gao Y.-H., Ling S., Chen T.-F.,
RA   Zhang G.-P., Gao Y.;
RT   "A high-throughput cell-based Gaussia luciferase reporter assay for
RT   measurement of CYP1A1, CYP2B6, and CYP3A4 induction.";
RL   Xenobiotica 51:752-763(2021).
//