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Cellosaurus HepG2 CAR-CYP2B6 clone 6 (CVCL_C0V4)

[Text version]
Cell line name HepG2 CAR-CYP2B6 clone 6
Accession CVCL_C0V4
Resource Identification Initiative To cite this cell line use: HepG2 CAR-CYP2B6 clone 6 (RRID:CVCL_C0V4)
Comments Population: Caucasian.
Characteristics: Transfected with both pcDNA3.1-hCAR and pGLuc-CYP2B6.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2615; CYP2B6.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 7969; NR1I3.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9BLZ2; Gaussia princeps luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=33896369; DOI=10.1080/00498254.2021.1918800
Li H., Wang Y.-G., Ma Z.-C., Gao Y.-H., Ling S., Chen T.-F., Zhang G.-P., Gao Y.
A high-throughput cell-based Gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Xenobiotica 51:752-763(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0V4
Encyclopedic resources Wikidata; Q112929719
Entry history
Entry creation23-Jun-2022
Last entry update10-Sep-2024
Version number6