Cellosaurus cell line A375M1 (CVCL

Cellosaurus A375M1 (CVCL_C0RN)

[Text version]

Cell line name

A375M1

Accession

CVCL_C0RN

Resource Identification Initiative

To cite this cell line use: A375M1 (RRID:CVCL_C0RN)

Comments

Population: Caucasian.
Characteristics: Metastatic. Established from pulmonary metastases obtained afer intravenous injection of the parent cell line into the tail veins of nude mice.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).

Disease

Amelanotic melanoma (NCIt: C3802)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_6233 (A375-P)
Children:

CVCL_C0RP (A375M2)

Sex of cell

Female

Age at sampling

54Y