ID   Caco-2 DUSP6 KO
AC   CVCL_C0R8
SY   DUSP6 KO Caco-2
DR   cancercelllines; CVCL_C0R8
DR   PRIDE; PXD029014
DR   Wikidata; Q112929357
RX   PubMed=27892926;
RX   PubMed=34818535;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 3072; DUSP6.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Omics: Deep phosphoproteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 05-10-23; Version: 5
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RX   PubMed=27892926; DOI=10.1038/nmicrobiol.2016.220;
RA   Ruan J.-W., Statt S., Huang C.-T., Tsai Y.-T., Kuo C.-C., Chan H.-L.,
RA   Liao Y.-C., Tan T.-H., Kao C.-Y.;
RT   "Dual-specificity phosphatase 6 deficiency regulates gut microbiome
RT   and transcriptome response against diet-induced obesity in mice.";
RL   Nat. Microbiol. 2:16220.1-16220.12(2016).
//
RX   PubMed=34818535; DOI=10.1016/j.celrep.2021.110016;
RA   Chang C.-S., Liao Y.-C., Huang C.-T., Lin C.-M., Cheung C.H.-Y.,
RA   Ruan J.-W., Yu W.-H., Tsai Y.-T., Lin I.-J., Huang C.-H., Liou J.-S.,
RA   Chou Y.-H., Chien H.-J., Chuang H.-L., Juan H.-F., Huang H.-C.,
RA   Chan H.-L., Liao Y.-C., Tang S.-C., Su Y.-W., Tan T.-H., Baumler A.J.,
RA   Kao C.-Y.;
RT   "Identification of a gut microbiota member that ameliorates
RT   DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient
RT   mice.";
RL   Cell Rep. 37:110016.1-110016.26(2021).
//