ID   HepaRG-POR#2
AC   CVCL_C0R1
DR   Wikidata; Q112929713
RX   PubMed=33441761;
CC   Characteristics: Not completely KO for POR, can be considered as a POR knockdown cell line (PubMed=33441761).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9208; POR.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3098; Hepatitis C infection
DI   NCIt; C3099; Hepatocellular carcinoma
DI   ORDO; Orphanet_88673; Hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C0QZ ! HepaRG(VC)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 19-12-24; Version: 6
//
RX   PubMed=33441761; DOI=10.1038/s41598-020-79952-1; PMCID=PMC7806635;
RA   Heintze T., Klein K., Hofmann U., Zanger U.M.;
RT   "Differential effects on human cytochromes P450 by CRISPR/Cas9-induced
RT   genetic knockout of cytochrome P450 reductase and cytochrome b5 in
RT   HepaRG cells.";
RL   Sci. Rep. 11:1000-1000(2021).
//