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Cellosaurus SK-N-AS RET KO clone C2 (CVCL_C0QA)

[Text version]
Cell line name SK-N-AS RET KO clone C2
Synonyms SK-N-AS C2
Accession CVCL_C0QA
Resource Identification Initiative To cite this cell line use: SK-N-AS RET KO clone C2 (RRID:CVCL_C0QA)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9967; RET.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1700 (SK-N-AS)
Sex of cell Female
Age at sampling 6Y
Category Cancer cell line
Publications

PubMed=33921066; DOI=10.3390/cancers13081909; PMCID=PMC8071449
Siaw J.T., Gabre J.L., Uckun E., Vigny M., Zhang W.-C., Van den Eynden J., Hallberg B., Palmer R.H., Guan J.-K.
Loss of RET promotes mesenchymal identity in neuroblastoma cells.
Cancers (Basel) 13:1909.1-1909.25(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0QA
Encyclopedic resources Wikidata; Q112930402
Gene expression databases ArrayExpress; E-MTAB-10032
Proteomic databases PRIDE; PXD024551
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number6