Cellosaurus PZ-TR (CVCL_C0NN)
| Cell line name | PZ-TR |
|---|---|
| Synonyms | Clone 4 |
| Accession | CVCL_C0NN |
| Resource Identification Initiative | To cite this cell line use: PZ-TR (RRID:CVCL_C0NN) |
| Comments | Population: Caucasian. Biotechnology: Used for as reporter cell line for the assessment of thyroid receptor (TR) transcriptional activity. Triiodothyronine (T3) induced luciferase activity in a dose-dependent manner, and the sensitivity of assay allowed for the detection of nanomolar T3 concentrations (PubMed=26208032). Characteristics: Expression of luciferase is under the control of a promoter containing two thyroid hormone response elements (TREs) separated by four nucleotides (DR4) followed by a SV40 promoter (PubMed=26208032). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
| Sequence variations |
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| Disease | Hepatoblastoma (NCIt: C3728) Hepatoblastoma (ORDO: Orphanet_449) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0027 (Hep-G2) |
| Sex of cell | Male |
| Age at sampling | 15Y |
| Category | Cancer cell line |
| Publications | PubMed=26208032; DOI=10.1021/acs.jafc.5b01519 |
| Cross-references | |
| Cell line databases/resources | cancercelllines; CVCL_C0NN |
| Encyclopedic resources | Wikidata; Q114312744 |
| Entry history | |
| Entry creation | 23-Jun-2022 |
| Last entry update | 10-Sep-2024 |
| Version number | 6 |