ID   XL58-TRE-Luc
AC   CVCL_C0ND
DR   Wikidata; Q112930580
RX   PubMed=16102758;
RX   PubMed=16179385;
CC   Group: Amphibian cell line.
CC   Biotechnology: Used in a thyroid hormone (TH) inducible primary screening assay for the identification and assessment of chemicals that interfere with the TH-signalling pathway within target cells (PubMed=16179385).
CC   Characteristics: Expression of luciferase is under the control of Xenopus T3-response elements (TREs). Expression of EGFP is under the control of the CMV promoter.
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
OX   NCBI_TaxID=8355; ! Xenopus laevis (African clawed frog)
HI   CVCL_C0NC ! XL58
SX   Sex unspecified
AG   Embryo
CA   Spontaneously immortalized cell line
DT   Created: 23-06-22; Last updated: 21-03-23; Version: 3
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RX   PubMed=16102758; DOI=10.1016/j.ygcen.2005.06.003;
RA   Sugiyama S.-i., Miyoshi H., Yamauchi K.;
RT   "Characteristics of a thyroid hormone responsive reporter gene
RT   transduced into a Xenopus laevis cell line using lentivirus vector.";
RL   Gen. Comp. Endocrinol. 144:270-279(2005).
//
RX   PubMed=16179385; DOI=10.1093/toxsci/kfi330;
RA   Sugiyama S.-i., Shimada N., Miyoshi H., Yamauchi K.;
RT   "Detection of thyroid system-disrupting chemicals using in vitro and
RT   in vivo screening assays in Xenopus laevis.";
RL   Toxicol. Sci. 88:367-374(2005).
//