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Cellosaurus A549-CEACAM1-4L (CVCL_C0DZ)

[Text version]
Cell line name A549-CEACAM1-4L
Accession CVCL_C0DZ
Resource Identification Initiative To cite this cell line use: A549-CEACAM1-4L (RRID:CVCL_C0DZ)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1814; CEACAM1 (Note=Isoform 4L).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=24743304; DOI=10.1371/journal.pone.0094106; PMCID=PMC3990526
Singer B.B., Opp L., Heinrich A., Schreiber F., Binding-Liermann R., Berrocal-Almanza L.C., Heyl K.A., Muller M.M., Weimann A., Zweigner J., Slevogt H.
Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.
PLoS ONE 9:E94106-E94106(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0DZ
Encyclopedic resources Wikidata; Q112927064
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number7