Cellosaurus cell line HTR.C/C (CVCL

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Cellosaurus HTR.C/C (CVCL_C0DN)

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Cross-references
Cell line name	HTR.C/C
Accession	CVCL_C0DN
Resource Identification Initiative	To cite this cell line use: HTR.C/C (RRID:CVCL_C0DN)
Comments	Selected for resistance to: ChEBI; CHEBI:472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Sequence variations	Mutation; MGI; MGI:96677; Kit; Simple; p.Asp818Tyr (c.2452G>T) (D814Y); Zygosity=Unspecified (from parent cell line).
Disease	Mouse mast cell neoplasm (NCIt: C21632)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: DBA/2.
Hierarchy	Parent: CVCL_C0DL (HTR.C)
Sex of cell	Male
Category	Cancer cell line
Publications	PubMed=8609411; DOI=10.4049/jimmunol.156.8.2909 Gajewski T.F., Fallarino F., Uyttenhove C., Boon T. Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization. J. Immunol. 156:2909-2917(1996) PubMed=9310829; DOI=10.1093/intimm/9.9.1259 Fallarino F., Ashikari A., Boon T., Gajewski T.F. Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells. Int. Immunol. 9:1259-1269(1997)
Encyclopedic resources	Wikidata; Q112929788
Entry history
Entry creation	23-Jun-2022
Last entry update	10-Sep-2024
Version number	4