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Cellosaurus A2780 PTX(16) (CVCL_C0D8)

[Text version]
Cell line name A2780 PTX(16)
Synonyms A2780 PTX (16); A/16 PTX-56d; A/16PTX-56d
Accession CVCL_C0D8
Resource Identification Initiative To cite this cell line use: A2780 PTX(16) (RRID:CVCL_C0D8)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0D7 (A2780 PTX(8))
Children:
CVCL_C0D9 (A2780 PTX(32))
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://portal.ichb.pl/commercialization-of-model-for-drug-resistant-cancer-cells/
Publications

Patent=PL420318A1
Szenajch J., Goralski M., Handschuh L., Siatkowski I., Szabelska-Beresewicz A., Swiercz A., Zyprych-Walczak J.
Human ovarian cancer cell culture model for paclitaxel-induced inverse resistance to paclitaxel and cisplatin and use thereof.
Patent number PL420318A1, 17-Jun-2019

PubMed=33287223; DOI=10.3390/ijms21239218; PMCID=PMC7730278
Szenajch J., Szabelska-Beresewicz A., Swiercz A., Zyprych-Walczak J., Siatkowski I., Goralski M., Synowiec A., Handschuh L.
Transcriptome remodeling in gradual development of inverse resistance between paclitaxel and cisplatin in ovarian cancer cells.
Int. J. Mol. Sci. 21:9218.1-9218.30(2020)

Cross-references
Cell line collections (Providers) CancerTools; 160731
Ximbio; 160731
Cell line databases/resources cancercelllines; CVCL_C0D8
Encyclopedic resources Wikidata; Q112927037
Gene expression databases GEO; GSM4845013
GEO; GSM4845014
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number6