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Cellosaurus 2C4 gamma2A/JAK2 (CVCL_C0D5)

[Text version]
Cell line name 2C4 gamma2A/JAK2
Synonyms Gamma2A Jak2; Gamma2A/JAK2
Accession CVCL_C0D5
Resource Identification Initiative To cite this cell line use: 2C4 gamma2A/JAK2 (RRID:CVCL_C0D5)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; 1639; CD2.
Genetic integration: Method=Transfection; Gene=MGI; MGI:96629; Jak2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0D4 (2C4 gamma2A)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=9001223; DOI=10.1128/mcb.17.2.695; PMCID=PMC231795
Kohlhuber F., Rogers N.C., Watling D., Feng J., Guschin D.Y., Briscoe J., Witthuhn B.A., Kotenko S.V., Pestka S., Stark G.R., Ihle J.N., Kerr I.M.
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Mol. Cell. Biol. 17:695-706(1997)

Cross-references
Cell line collections (Providers) CancerTools; 151681
Ximbio; 151681
Cell line databases/resources cancercelllines; CVCL_C0D5
Encyclopedic resources Wikidata; Q112926938
Entry history
Entry creation23-Jun-2022
Last entry update10-Sep-2024
Version number7