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Cellosaurus HEK293T SOD2 KO (CVCL_C0CZ)

[Text version]
Cell line name HEK293T SOD2 KO
Synonyms SOD2-/- HEK293T; SOD2-null HEK293T; SOD2
Accession CVCL_C0CZ
Resource Identification Initiative To cite this cell line use: HEK293T SOD2 KO (RRID:CVCL_C0CZ)
Comments Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11180; SOD2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA).
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0063 (HEK293T)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=26208779; DOI=10.1016/j.freeradbiomed.2015.07.017; PMCID=PMC4890619
Cramer-Morales K.L., Heer C.D., Mapuskar K.A., Domann F.E.
SOD2 targeted gene editing by CRISPR/Cas9 yields human cells devoid of MnSOD.
Free Radic. Biol. Med. 89:379-386(2015)

PubMed=33585836; DOI=10.33696/pathology.1.009; PMCID=PMC7876477
Cramer-Morales K.L., Heer C.D., Mapuskar K.A., Domann F.E.
Succinate accumulation links mitochondrial MnSOD depletion to aberrant nuclear DNA methylation and altered cell fate.
J. Exp. Pathol. (Wilmington) 1:60-70(2020)

Cross-references
Cell line collections (Providers) CancerTools; 153875
Ximbio; 153875
Encyclopedic resources Wikidata; Q112929699
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number7